Author:
PAGÈS F.,LARRIEU S.,SIMOES J.,LENABAT P.,KURTKOWIAK B.,GUERNIER V.,LE MINTER G.,LAGADEC E.,GOMARD Y.,MICHAULT A.,JAFFAR-BANDJEE M. C.,DELLAGI K.,PICARDEAU M.,TORTOSA P.,FILLEUL L.
Abstract
SUMMARYWe report herein the investigation of a leptospirosis outbreak occurring in triathlon competitors on Réunion Island, Indian Ocean. All participants were contacted by phone or email and answered a questionnaire. Detection and molecular characterization of pathogenicLeptospirawas conducted in inpatients and in rodents trapped at the vicinity of the event. Of the 160 athletes competing, 101 (63·1%) agreed to participate in the study. Leptospirosis was biologically confirmed for 9/10 suspected cases either by real-time PCR or serological tests (MAT or ELISA). The total attack rate, children's attack rate, swimmers’ attack rate, and the attack rate in adult swimmers were respectively estimated at 8·1% [95% confidence interval (CI) 4·3–14·7], 0%, 12·7% (95% CI 6·8–22·4) and 23·1% (95% CI 12·6–33·8). Leptospirosis cases reported significantly more wounds [risk ratio (RR) 4·5, 95% CI 1·6–13], wore complete neoprene suits less often (RR 4·3, 95% CI 1·3–14·5) and were most frequently unlicensed (RR 6·6, 95% CI 2·9–14·8). The epidemiological investigation supported that some measures such as the use of neoprene suits proved efficient in protecting swimmers against infection. PCR detection in rats revealed highLeptospirainfection rates. Partial sequencing of the 16S gene and serology on both human and animal samples strongly suggests that rats were the main contaminators and were likely at the origin of the infection in humans.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Reference40 articles.
1. Human Leptospirosis on Reunion Island: Past and Current Burden
2. A leptospirosis outbreak on Guam associated with an athletic event;Haddock;Pacific Health Dialog,2002
3. Leptospirosis in “Eco-Challenge” Athletes, Malaysian Borneo, 2000
4. New contributions to the study of leptospirosis in Reunion. Study of 70 cases, 18 of which fatal: clinical and biological aspects. Physiopathological considerations;Gauthier;Bulletin de la Société de pathologie exotique et de ses filiales,1969
5. Endemicity of leptospirosis in domestic and wild animal species from Reunion Island (Indian Ocean)
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献