Author:
OURA C. A. L.,IVENS P. A. S.,BACHANEK-BANKOWSKA K.,BIN-TARIF A.,JALLOW D. B.,SAILLEAU C.,MAAN S.,MERTENS P. C.,BATTEN C. A.
Abstract
SUMMARYAfrican horse sickness virus serotype 9 (AHSV-9) has been known for some time to be circulating amongst equids in West Africa without causing any clinical disease in indigenous horse populations. Whether this is due to local breeds of horses being resistant to disease or whether the AHSV-9 strains circulating are avirulent is currently unknown. This study shows that the majority (96%) of horses and donkeys sampled across The Gambia were seropositive for AHS, despite most being unvaccinated and having no previous history of showing clinical signs of AHS. Most young horses (<3 years) were seropositive with neutralizing antibodies specific to AHSV-9. Eight young equids (<3 years) were positive for AHSV-9 by serotype-specific RT–PCR and live AHSV-9 was isolated from two of these horses. Sequence analysis revealed the presence of an AHSV-9 strain showing 100% identity to Seg-2 of the AHSV-9 reference strain, indicating that the virus circulating in The Gambia was highly likely to have been derived from a live-attenuated AHSV-9 vaccine strain.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Reference16 articles.
1. Identification and differentiation of the nine African horse sickness virus serotypes by RT–PCR amplification of the serotype-specific genome segment 2
2. Antibody in Nigerian animals to African horse sickness serotype 9
3. African horse sickness and equine infectious anaemia serology in The Gambia
4. Emerging diseases of animals II. African horse sickness;Howell;FAO Agricultural Studies,1963
5. African horse sickness in Senegal: the state of natural and/or acquired immunity in horses in a recent foci;Sarr;Revue d'Elevage et de Medecine Veterinaire des Pays Tropicaux (Paris),1988
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献