Author:
Barrow P. A.,Hassan J. O.,Berchieri A.
Abstract
SUMMARYChickens given orally at 4 days of age a smooth spectinomycin resistant mutant (Spcr) ofSalmonella typhimuriumstrain F98 excreted the organism in their faeces for approximately 4 weeks. Following oral administration of a nalidixic acid resistant (Nalr) mutant of the same strain 4 weeks later when later when the chickens had virtually cleared themselves of the first infection, these chickens excreted far fewer salmonella organisms and for a shorter time than did a previously uninfected control group of chickens which were infected at the same time with the Nalrmutant. Chickens inoculated intramuscularly at 4 days developed a similar immunity to challenge and also excreted the immunizing strain in their faeces. In contrast intramuscular inoculation or incorporation into the food of formalin-killedS. typhimuriumorganisms had little lasting effect on the faecal excretion of the challenge strain. Two attenuated mutants of strain F98 Nalrwere produced: one was a rough strain produced by lytic bacteriophage and the other was anaro Aauxotrophic mutant which had been cured of the 85 kilobase–pair virulence–associated plasmid. These mutants were avirulent for chickens, mice, calves and man and when ingested by human volunteers did not persist in the faeces. When inoculated intramuscularly into chickens they produced an early reduction in faecal excretion of the challenge strain (Spcr) which was not maintained. Oral administration of both strains produced reductions in faecal excretion of the challenge strain. This was much more noticeable with the rough strain which was itself excreted for a much longer period than the parent strain.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
88 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献