Author:
COLQUHOUN A. J.,NICHOLSON K. G.,BOTHA J. L.,RAYMOND N. T.
Abstract
The effectiveness of influenza vaccination in reducing
hospitalization of people with diabetes
for influenza, pneumonia, or diabetic events during influenza epidemics
was assessed in a case
control study in Leicestershire, England. Cases were 80 patients on
the Leicestershire Diabetes
Register who were admitted and discharged from hospital with International
Classification of
Disease codes for pneumonia, bronchitis, influenza, diabetic ketoacidosis,
coma
and diabetes,
without mention of complications, during the influenza epidemics of
1989–90 and 1993. One
hundred and sixty-controls, who were not admitted to hospital during this
period, were randomly selected from the Register. Immunization against
influenza was
assessed in 37 cases
and 77 controls for whom consent was obtained to access their clinical
notes and for whom
notes were available. Significant association was detected between reduction
in hospitalization
and influenza vaccination during the period immediately preceding an
epidemic. Multiple
logistic regression analysis estimated that influenza vaccination reduced
hospital admissions by
79% (95% CI 19–95%) during the two epidemics, after adjustment for
potential confounders.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
121 articles.
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