Author:
JIN L.,SUN Y. J.,GE L.,BROWN D. W. G.
Abstract
We report the co-circulation of a new lineage of measles virus
(MV) and an Edmonston-like
(Ed-like) genotype of MV in China during 1995–7. Sequence analysis
of 25 strains was
performed on a 282 nucleotides (nt) region of the nucleoprotein (N) gene,
a 450-nt region of
the haemagglutinin (H) gene and a 152-nt region of the matrix (M) gene
by direct sequencing
of RT-PCR amplicons obtained from clinical specimens. The entire H gene
was sequenced
from two strains. The results showed that 24/25 Chinese strains belonged
to a new genogroup
and were distinct from the vaccine strains used in China and the UK, and
also from MV
strains previously described in Europe, Africa and the USA. The remaining
strain was Ed-like.
Two strains of the new genotype (IV) and one of the Ed-like genotype were
also detected in
the UK in 1996.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
20 articles.
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