Author:
DE MELKER H. E.,CONYN-VAN SPAENDONCK M. A. E.
Abstract
Mass vaccination can change the epidemiological dynamics of infectious
diseases. It may result
in a limited persistence of natural and vaccine-induced immunity and a
higher mean age of
infection, which may lead to a greater risk of complications. The epidemiological
situation
should be monitored and immunosurveillance based on the assessment of specific
antibodies
against vaccine-preventable diseases in human serum is one of the tools.
In order to estimate
the immunity of the Dutch population reliably, a large-scale, population-based,
collection of
serum samples was established (8359 sera in a nation-wide sampling and
1589 sera from
municipalities with low vaccine coverage). In contrast to collecting residual
sera from
laboratories, this approach gains extensive information by means of a questionnaire
regarding
the determinants of the immune status and the risk factors for the transmission
of infectious
diseases in general. The population-based approach gives a better guarantee
that the data are
representative than collecting sera from laboratories does.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
83 articles.
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