Species and antimicrobial susceptibility testing of coagulase-negative staphylococci in periprosthetic joint infections

Abstract

AbstractThe objective was to evaluate the distribution of coagulase-negative staphylococci (CNS) involved in periprosthetic-joint infections (PJIs) and to describe their susceptibility profile to antibiotics. We conducted a multicentre retrospective study in France, including 215 CNS PJIs between 2011 and 2015. CNS PJIs involved knees in 54% of the cases, hips in 39%, other sites in 7%. The distribution of the 215 strains was:Staphylococcus epidermidis129 (60%),Staphylococcus capitis24 (11%),Staphylococcus lugdunensis21 (10%),Staphylococcus warneri8 (4%),Staphylococcus hominis7 (3%),Staphylococcus haemolyticus7 (3%). More than half of the strains (52.1%) were resistant to methicillin, 40.9% to ofloxacin, 20% to rifampicin. The species most resistant to antibiotics wereS.hominis,S. haemolyticus,S. epidermidis,with 69.7% of the strains resistant to methicillin and 30% simultaneously resistant to clindamycin, cotrimoxazole, ofloxacin and rifampicin. No strain was resistant to linezolid or daptomycin. In this study on CNS involved in PJIs, resistance to methicillin is greater than 50%.S. epidermidisis the most frequent and resistant species to antibiotics. Emerging species suchS. lugdunensis,S. capitisandStaphylococcus capraeexhibit profiles more sensitive to antibiotics. The antibiotics most often activein vitroare linezolid and daptomycin.