Retrospective analysis of whole genome sequencing compared to prospective typing data in further informing the epidemiological investigation of an outbreak of Shigella sonnei in the UK

Author:

McDONNELL J.,DALLMAN T.,ATKIN S.,TURBITT D. A.,CONNOR T. R.,GRANT K. A.,THOMSON N. R.,JENKINS C.

Abstract

SUMMARYThe aim of this study was to retrospectively assess the value of whole genome sequencing (WGS) compared to conventional typing methods in the investigation and control of an outbreak of Shigella sonnei in the Orthodox Jewish (OJ) community in the UK. The genome sequence analysis showed that the strains implicated in the outbreak formed three phylogenetically distinct clusters. One cluster represented cases associated with recent exposure to a single strain, whereas the other two clusters represented related but distinct strains of S. sonnei circulating in the OJ community across the UK. The WGS data challenged the conclusions drawn during the initial outbreak investigation and allowed cases of dysentery to be implicated or ruled out of the outbreak that were previously misclassified. This study showed that the resolution achieved using WGS would have clearly defined the outbreak, thus facilitating the promotion of infection control measures within local schools and the dissemination of a stronger public health message to the community.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Epidemiology

Reference19 articles.

1. Tablet--next generation sequence assembly visualization

2. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies;Kotloff;Bulletin of the World Health Organization,1999

3. Addiman S , Is history repeating itself? Shigella sonnei PT P outbreak in the Orthodox Jewish community in Hackney, London. Health Protection Conference, 15–17 September 2008; Warwick, UK. Poster presentation.

4. Multilocus Variable-Number Tandem-Repeat Analysis for Molecular Typing of Shigella sonnei

5. A recurring outbreak of Shigella sonnei among traditionally observant Jewish children in New York City: the risks of daycare and household transmission

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3