Abstract
SUMMARYSalmonella entericasubsp.entericaserovar Dublin (S.Dublin) is one of the non-typhoidalSalmonella(NTS); however, a relatively high proportion of human infections are associated with invasive disease. We applied whole genome sequencing to representative invasive and non-invasive clinical isolates ofS.Dublin to determine the genomic variations among them and to investigate the underlying genetic determinants associated with invasiveness inS.Dublin. Although no particular genomic variation was found to differentiate in invasive and non-invasive isolates four virulence factors were detected within the genome of all isolates including two different type VI secretion systems (T6SS) encoded on twoSalmonellapathogenicity islands (SPI), including SPI-6 (T6SSSPI-6) and SPI-19 (T6SSSPI-19), an intact lambdoid prophage (Gifsy-2-like prophage) that contributes significantly to the virulence and pathogenesis ofSalmonellaserotypes in addition to a virulence plasmid. These four virulence factors may all contribute to the potential ofS.Dublin to cause invasive disease in humans.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
23 articles.
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