Author:
Ansell D. M.,Samuel A. R.,Carpenter W. C.,Knowles N. J.
Abstract
SummaryThe sequence of 165 nucleotides at the 3´ end of the 1D (VP1) gene of foot-and-mouth disease (FMD) virus was determined for 44 type Asia 1 strains isolated from throughout Asia between 1954–92. Analysis of the relationships between the virus genomes showed epidemiological links not previously evident. The possible origin of the only outbreak of FMD Asia 1 to have occurred in Europe, in Greece in 1984, was identified because the nucleotide sequence of this virus was closely-related to the sequences of those present in the Middle East between 1983–5.Variation in the region sequenced was not as great as that seen in the other FMDV serotypes and all viruses shared greater than 85% nucleotide identity. Thus all the virus isolates examined were considered to belong to a single genotype.A database of Asia 1 virus sequences has been established which will facilitate the rapid analysis of new outbreaks strains.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
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