Abstract
The effect of a given concentration of
TrenimonR (6 ×
20−8 mol/1) on the
lymphocytes of 11 healthy subjects with
morphologically abnormal karyotype was analysed in
vitro. The research included 6 subjects with
balanced translocations, one of them with a
centric fusion. Of the remaining 5 subjects, 2 had
a duplication in the paracentric region, 1 showed
an inversion, and 2 had a marker
chromosome.
In the group with morphologically abnormal
chromosomes a higher sensibility to the influence
of TrenimonR was found as
compared with a control group with morphologically
normal karyotype. The subjects with an atypical
karyotype had 36 to 65% aberrations, the control
group 28%. A localization of the breaks showed no
increased aberration rates in the morphologically
abnormal chromosomes.
Publisher
Cambridge University Press (CUP)
Cited by
4 articles.
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