Fetal cardiovascular reflex responses to hypoxaemia

Author:

Giussani Dino A,Spencer John AD,Hanson Mark A

Abstract

The fetus mounts a coordinated cardiovascular response to an insult of acute hypoxaemia which involves neural and endocrine components. During acute hypoxaemia in late pregnancy there is a transient bradycardia, a gradual increase in arterial blood pressure and an increase in heart rate variability. In addition, there is a redistribution of the combined ventricular output favouring the cerebral, myocardial and adrenal circulations by shunting blood away from the peripheral circulations. A component of the increase in peripheral vascular resistance and the increase in arterial blood pressure during acute hypoxaemia is mediated via increases in plasma concentrations of vasoconstrictor hormones such as vasopressin, angiotensin II and neuropeptide Y. Whilst an increase in plasma ACTH and cortisol is also seen during acute hypoxaemia, their contribution to cardiovascular control in fetal sheep is less clear.Evidence has been presented to suggest that a number of these cardiovascular and endocrine responses to acute hypoxaemia are chemorefiex in nature, mediated principally by carotid chemoreceptor afferents. In addition, this reflex may be modifiable in terms of changes in magnitude and gain: first, by an influence of the intrauterine environment during chronic hypoxaemia and second, through genetic influences, in animals adapted to life at high altitude.

Publisher

Cambridge University Press (CUP)

Subject

Obstetrics and Gynaecology,Pediatrics, Perinatology, and Child Health

Reference199 articles.

1. Fetal breathing adaptation to prolonged hypoxaemia in sheep;Koos;J Dev Physiol,1988

2. DNA synthesis is reduced in selected fetal tissues during prolonged hypoxemia;Hooper;Am J Physiol,1991

3. Fetal endocrine responses to prolonged hypoxemia in sheep;Hooper;Am J Physiol,1990

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