Sodium balance in pregnancy

Abstract

Sodium is the major cation in the extracellular fluid volume (ECFV) and as such, is the most important determinant of osmolality and of the volume of this fluid compartment. Hence any alteration in the control of body sodium will be reflected by changes in the ECFV, including the maternal plasma volume. There is no doubt that expansion of the plasma volume is a necessary and desirable event during pregnancy, influencing positively both maternal and fetal outcome. Therefore, studies of sodium balance in pregnancy provide important information relevant to both mother and fetus.