Variable expression of molecular markers in juvenile nasopharyngeal angiofibroma

Author:

Mishra A,Pandey A,Mishra S C

Abstract

AbstractBackground:Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma.Methods:Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports.Results:Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident. Molecular data have been reported for only 11 countries, indicating a clear geographical bias. Only 58 markers have been studied, and most are yet to be validated.Conclusion:Research into the molecular epidemiology of juvenile nasopharyngeal angiofibroma is still in its infancy. Although the molecular variation is not well understood, data obtained so far have prompted important research questions. Hence, multicentre collaborative molecular studies are needed to establish the aetiopathogenesis and establish molecular surrogates for clinical characteristics.

Publisher

Cambridge University Press (CUP)

Subject

Otorhinolaryngology,General Medicine

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Microvessel density (Cluster of Differentiation-34 & Vascular Endothelial growth factor) in Nasopharyngeal Angiofibroma: Clinical correlation;International Journal of Pediatric Otorhinolaryngology;2023-11

2. A Narrative Review of Flutamide in Juvenile Nasopharyngeal Angiofibroma;Indian Journal of Otolaryngology and Head & Neck Surgery;2023-05-03

3. Juvenile Nasopharyngeal Angiofibroma: An Aberrant Case Report;Cureus;2022-04-21

4. Juvenile Nasopharyngeal Angiofibroma;Pharynx - Diagnosis and Treatment;2021-09-08

5. Pseudogenes in Juvenile Nasopharyngeal Angiofibroma: First Pilot Observation;Indian Journal of Otolaryngology and Head & Neck Surgery;2021-01-05

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