Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure

Abstract

AbstractBackgroundThere are no definite guidelines regarding the most adequate steroid regimens for acute acoustic trauma.ObjectiveTo elucidate the dose-dependent differing benefits of oral steroids on hearing improvement following acute acoustic trauma.MethodsTwenty-nine patients treated with oral steroids following a diagnosis of unilateral acute acoustic trauma were retrospectively reviewed. Patients were sorted into two groups with an oral steroid regimen. Group 1 received a 14-day course of treatment: 60 mg prednisolone daily for 10 days, tapering off over days 11–14. Group 2 received prednisolone for a total of 10 days: 60 mg for 5 days, tapering down each day for the remainder. Multivariable linear regression analysis was performed to evaluate the factors associated with the hearing gain.ResultsIn the multivariable regression (R2 = 0.51, p < 0.001), patients in group 1 showed more significant improvement in the degree of hearing gain compared to group 2 (p = 0.03).ConclusionAfter comparing the differing benefits of oral steroids on hearing improvement by dosage, we recommend a high dose of prednisolone (60 mg per day) for 10 days, tapering over the remaining 4 days, for better hearing recovery following acute acoustic trauma.