Role of cyclins D1 and D3 in vestibular schwannoma

Abstract

AbstractBackground:Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.Objective:This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D1, cyclin D3and Ki-67, in vestibular schwannoma patients separated into two age groups: ≤40 years or >40 years.Method:Immunohistochemical detection of cyclin D1, cyclin D3and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.Results:The proliferation index of vestibular schwannomas was statistically higher in the ≤40 years age group compared to that in the >40 years age group (mean of 4.52vs3.27, respectively;p = 0.01). Overexpression of cyclin D1and cyclin D3was found in 68 per cent and 44 per cent of tumours, respectively.Conclusion:There was an increased Ki-67 proliferation index in the younger age group that appears to correlate with clinical behaviour. Vestibular schwannomas in both age groups show increased expression of cyclin D1and cyclin D3.