Protective effects of vitamins E, B and C andl-carnitine in the prevention of cisplatin-induced ototoxicity in rats

Abstract

AbstractObjective:This experimental study aimed to investigate the effects of vitamins E, B and C andl-carnitine in preventing cisplatin-induced ototoxicity.Methods:Twenty-five adult, male, Wistar albino rats were randomly allocated to receive intraperitoneal cisplatin either alone or preceded by vitamins B, E or C orl-carnitine. Auditory brainstem response (i.e. hearing thresholds and wave I–IV intervals) and distortion product otoacoustic emissions (i.e. signal-to-noise ratios) were recorded before and 72 hours after cisplatin administration.Results:The following statistically significant differences were seen: control group pre-vspost-treatment wave I–IV interval values (p < 0.05); controlvsvitamin E and B groups' I–IV interval values (p < 0.05); controlvsother groups' hearing thresholds; vitamin Evsvitamin B and C andl-carnitine groups' hearing thresholds (p < 0.05); and vitamin Bvsvitamin C andl-carnitine groups' hearing thresholds (p < 0.05). Statistically significant decreases were seen when comparing the initial and final signal-to-noise ratios in the control, vitamin B andl-carnitine groups (2000 and 3000 Hz;p < 0.01), and the initial and final signal-to-noise ratios in the control group (at 4000 Hz;p < 0.01).Conclusion:Vitamins B, E and C andl-carnitine appear to reduce cisplatin-induced ototoxicity in rats. The use of such additional treatments to decrease cisplatin-induced ototoxicity in humans is still under discussion.