Author:
Ashmarin Igor P.,Danilova Raisa A.,Rud'ko Olga I.,Belopolskaya Maria V.,Obukhova Maria F.,Shmalgausen Elena V.
Abstract
The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.
Publisher
Cambridge University Press (CUP)
Subject
Linguistics and Language,General Psychology,Language and Linguistics
Reference26 articles.
1. Saturable transport of peptides across the blood-brain barrier
2. Reduced Primary Antibody Responses in a Genetic Animal Model of Depression
3. Dlitel'naya korrektsia funktsii mozga, perspektivy immunologicheskikh podkhodov;Ashmarin;Vestnik RAMN,2001
4. Antitela k serotoninu I ikh vozmozhnaya rol' pri parkinsonizme;Kryzhanovsky;Zhurnal Nevropatalogii I psykhiatrii,1994
5. Cellular immune reactions and blood cerebrosplnal fluid barrier dysfunction in guinea pigs;Relber;Neurochem. Res.,1988
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献