Author:
JAKEMAN G. N.,SAUL A.,HOGARTH W. L.,COLLINS W. E.
Abstract
While anaemia has long been recognized as a consequence of acute infections with malaria, the relative contributions of
direct erythrocyte destruction by parasites, destruction of uninfected erythrocytes and changes in erythropoiesis have been
unclear. Fitting of parasitaemia and anaemia data from neurosyphilis patients undergoing malaria therapy to a mathematical
model shows that in these patients, an average of 8·5 erythrocytes were destroyed in addition to each erythrocyte
observed to become parasitized. The model also showed that dyserythropoiesis plays an insignificant role in the resulting
anaemia. The anaemia occurs before a substantial antibody response to parasites or erythrocytes could be generated. We
postulate that uninfected erythrocyte destruction occurs through phagocytosis of erythrocytes bound to merozoites killed
as a result of the accompanying malaria paroxysms.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
204 articles.
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