Studies on the resistance of rats to the nematodeNippostrongylus muris(Yokogawa, 1920). III. Attempt to transfer immunity adoptively

Abstract

Two attempts to transfer immunity againstN. muristo rats using the lymph node and spleen cells from actively immunized donors were unsuccessful. Experiments showed that the rats were sufficiently inbred, that the transfer technique was satisfactory, and that the donors were adequately immunized. The rats' competence as donors for adoptive transfer was demonstrated with sheep red cells as antigen. The adoptive transfer of immunity against sheep red cells was successful in recipients whose donors had sheep red cells only and noN. muris. There was no detectable transfer of immunity againstN. murisor sheep red cells to recipients whose donors had received both.We are very grateful to Miss Kathleen O'Brien for technical assistance, to Professor P. B. Medawar, F.R.S., for his help and advice and to Dr E. J. Delorme for showing us Professor M. F. A. Woodruff's skin-grafting technique.