Abstract
Transmission electron microscopy was used to study
Toxoplasma gondii infections in the small intestines of
Swiss-Webster
mice at 2–48 h post-feeding of oocysts (p.f.). Sporozoites
passed through intestinal epithelial cells (enterocytes and goblet
cells) and infected all cells except red blood cells in the lamina
propria. Parasites in intestinal epithelial cells or in cells
in the lamina propria were located within a single type of
parasitophorous vacuole, which contained exocytosed electron-dense
material and well-developed tubulovesicular membranous networks.
Sporozoites did not infect intraepithelial
lymphocytes (IELs), but at 48 h p.f. IELs had become infected with
tachyzoites arising from those that had developed
in the lamina propria. At 48 h p.f., the lamina propria contained
numerous tachyzoites, much cellular debris, and few
intact cells. The intestinal epithelium exhibited limited
cytopathological changes except for villar fusion, slight vacuolation,
and cell separation at the bases of enterocytes.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
62 articles.
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