Author:
ALIFRANGIS M.,LEMNGE M. M.,MOON R.,THEISEN M.,BYGBJERG I.,RIDLEY R. G.,JAKOBSEN P. H.
Abstract
A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic.
Blood samples were collected from children (1–4 years) and tested for IgG antibody reactivity against 2 recombinant
protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The data were related to the
prevalence of malarial disease and single P. falciparum or mixed Plasmodium infections. Fever ([ges ]37·5 °C) in combination
with parasite densities >5000/μl were used to distinguish between children with asymptomatic malaria infections and
those with acute clinical disease. Furthermore, C-reactive protein (CRP) was applied as a surrogate marker of malaria
morbidity. The prevalence of Plasmodium infections was 96·0%. Eleven children were defined as clinical malaria cases,
all with single P. falciparum infections. The density of P. falciparum was significantly lower in children with mixed
Plasmodium infections compared to those with single P. falciparum infections. Children with asymptomatic P. falciparum
infections had higher IgG reactivities to rRAP-1, compared to IgG reactivities of children with malarial disease. Children
with mixed Plasmodium infections generally showed elevated IgG reactivity to rRAP-1, when compared to children with
single P. falciparum infections. The possible relationship between mixed species infections, clinical outcome of the disease
and antibody responses to RAP-1 is discussed.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
29 articles.
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