Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil againstDactylogyrus intermedius

Abstract

SUMMARYUtilization of chemical pesticide to control monogenean diseases is often restricted in many countries due to the development of pesticide resistance and concerns of chemical residues and environmental contamination. Thus, the use of antiparasitic agents from plants has been explored as a possible way for controlling monogenean infections. Extracts fromCinnamomum cassiawere investigated underin vivoconditions againstDactylogyrus intermediusin goldfish. The two bioactive compounds, cinnamaldehyde and cinnamic acid, were identified using nuclear magnetic resonance and electrospray ionization mass spectrometry. The 48 h median effective concentrations (EC50) for these compounds againstD. intermediuswere 0·57 and 6·32 mg L−1, respectively. The LD50of cinnamaldehyde and cinnamic acid were 13·34 and 59·66 mg L−1to goldfish in 48 h acute toxicity tests, respectively. These data confirm that cinnamaldehyde is effective againstD. intermedius, and the cinnamaldehyde exhibits potential for the development of a candidate antiparasitic agent.