Genetic control of immune responses to parasites: selection for responsiveness and non-responsiveness to Trichuris muris in random-bred mice

Author:

Wakelin D.

Abstract

Populations of Schofield strain, random-bred mice were shown to have a bimodal variation in ability to bring about immune expulsion of the nematode Trichuris muris. This variation was genetically determined and independent of the size of infection experienced. The proportion of mice unable to achieve worm expulsion (non-responders) was relatively constant in various populations of the strain but was increased by selective breeding from mice of known status. Crosses made between non-responder and responder mice produced progeny that were almost all (92%) of responder phenotype, showing that the ability to achieve worm expulsion was inherited as a dominant characteristic. It is suggested that the genetic control involves a small number of genes; the possible immunological mechanisms by which control is mediated are briefly discussed.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Animal Science and Zoology,Parasitology

Reference22 articles.

1. INHERITED AND ACQUIRED FACTORS IN RESISTANCE TO INFECTION

2. The inheritance of resistance to trichostrongylidosis in sheep. I. Demonstration of the validity of the phenomena;Whitlock;Cornell Veterinarian,1958

3. A study of the inheritance of resistance to trichostrongylidosis in sheep;Whitlock;Cornell Veterinarian,1955

4. Immunity to Hymenolepis citelli by Peromyscus maniculatus: Genetic Control and Ecological Implications

5. Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice

Cited by 38 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Detection of a quantitative trait locus associated with resistance to Ascaris suum infection in pigs;International Journal for Parasitology;2012-04

2. Immune-mediated regulation of chronic intestinal nematode infection;Immunological Reviews;2004-10

3. Chasing the genes that control resistance to gastrointestinal nematodes;Journal of Helminthology;2003-06

4. Acquired resistance affects male sexual display and female choice in guppies;Proceedings of the Royal Society of London. Series B: Biological Sciences;1998-04-22

5. Genetic resistance to parasitic infection;Revue Scientifique et Technique de l'OIE;1998-04-01

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3