Author:
ROSA LUCIANA DALLA,DA SILVA ALEKSANDRO S.,GRESSLER LUCAS T.,OLIVEIRA CAMILA B.,DAMBRÓS MARIA G. C.,MILETTI LUIZ C.,FRANÇA RAQUELI T.,LOPES SONIA T. A.,SAMARA YASMIN N.,DA VEIGA MARCELO L.,MONTEIRO SILVIA G.
Abstract
SUMMARYThe aim of this study was to evaluate the anti-trypanosomal effect of treatment with 3′-deoxyadenosine (cordycepin) combined with deoxycoformycin (pentostatin: inhibitor of the enzyme adenosine deaminase)in vitroby using mice experimentally infected withTrypanosoma evansi. In vitro, a dose-dependent trypanocidal effect of cordycepin was observed against the parasite. In thein vivotrials, the two drugs were used individually and in combination of different doses. The drugs when used individually had no curative effect on infected mice. However, the combination of cordycepin (2 mg kg−1) and pentostatin (2 mg kg−1) was 100% effective in theT. evansi-infected groups. There was an increase in levels of some biochemical parameters, especially on liver enzymes, which were accompanied by histological lesions in the liver and kidneys. Based on these results we conclude that treatment using the combination of 3′-deoxyadenosine with deoxycoformycin has a curative effect on mice infected withT. evansi. However, the therapeutic protocol tested led to liver and kidney damage, manifested by hepatotoxicity and nephrotoxicity.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
22 articles.
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