Author:
COX M. J.,AZEVEDO R. S.,NOKES D. J.,BEARDS G. M.,McCRAE M. A.,MASSAD E.,MEDLEY G. F.
Abstract
Age-specific patterns of rotavirus infection were investigated
using a randomly selected and
representative sample of sera from a suburban community of São
Paulo, Brazil screened for
class-specific antibodies to group A rotavirus. Age-serology of anti-rotavirus
IgG showed
primary infection predominant in young infants with a median age of around
18 months
consistent with IgM serology suggesting highest rates of recent infection
between ages 4 and 48
months. Anti-rotavirus serum IgA prevalence increased gradually with age.
Paired samples
from infants, collected 1 month apart, indicated high exposure rates with
seroconversion
occurring in several infants during the reported low transmission season.
Between 5 and 10%
of adults had elevated IgM levels indicative of recent infection and, potentially,
of an
important contribution adults may play to rotavirus transmission. Further
understanding of the
dynamics of rotavirus transmission within populations, at group and serotype
level, would
benefit the design and monitoring of future immunization programmes.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
10 articles.
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