Author:
PRIEST J. W.,MOSS D. M.,ARNOLD B. F.,HAMLIN K.,JONES C. C.,LAMMIE P. J.
Abstract
SUMMARYToxoplasma gondiiis a globally distributed parasitic protozoan that infects most warm-blooded animals. We incorporated a bead coupled with recombinant SAG2A protein into our Neglected Tropical Disease (NTD) multiplex bead assay (MBA) panel and used it to determineToxoplasmainfection rates in two studies in Haiti. In a longitudinal cohort study of children aged 0–11 years, the infection rate varied with age reaching a maximum of 0·131 infections/year in children aged 3 years [95% confidence interval (CI) 0·065–0·204]. The median time to seroconversion was estimated to be 9·7 years (95% CI 7·6–∞). In a cross-sectional, community-wide survey of residents of all ages, we determined an overall seroprevalence of 28·2%. The seroprevalence age curve from the cross-sectional study also suggested that the force of infection varied with age and peaked at 0·057 infections/year (95% CI 0·033–0·080) at age 2·6 years. Integration of theToxoplasmaMBA into NTD surveys may allow for better estimates of the potential burden of congenital toxoplasmosis in underserved regions.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
19 articles.
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