Class-specific herpes simplex virus antibodies in sera and cervical secretions from patients with cervical neoplasia: a multi-group comparison

Author:

Dale G. E.,Coleman R. M.,Best J. M.,Benetato B. B. B.,Drew N. C.,Chinn S.,Papacosta A. O.,Nahmias A. J.

Abstract

SummarySerum and cervical secretions were collected from patients with cervical dysplasia, carcinoma-in-situ (CIS), squamous cell carcinoma (cervical SCC), and controls with normal cervices, attending clinics within the West Lambeth Health District, London. Enzyme-linked immunosorbent assays were used to examine cervical secretory IgA (sIgA) and serum IgG and IgA antibodies to herpes simplex virus (HSV). Sexual and demographic factors were considered during data analysis, which involved fitting multiple linear or multiple logistic regressions to HSV antibody levels. Prevalence of sIgA-HSV and levels of serum antibodies to HSV in all groups were compared with those of gynaecology controls. Caucasian women with mild dysplasia had a significantly higher prevalence of sIgA-HSV. Serum IgG levels to HSV (IgG-HSV) were significantly elevated in women with mild dysplasia and severe dysplasia/ClS. Serum IgA levels to HSV1 (IgG-HSV1) were significantly higher in women with cervical SCC (after adjusting for smoking habits) and other genital tumours. Significantly higher levels of serum IgA to HSV2 (IgA-HSV2) were also found among Caucasian women with cervical SCC. The possible role of HSV as a co-factor in cervical carcinogenesis is discussed.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Epidemiology

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Association between human herpesvirus infection and cervical carcinoma: a systematic review and meta-analysis;Virology Journal;2023-12-04

2. Evasion of Host Immune Responses by Tumours and Viruses;Ciba Foundation Symposium 187 - Vaccines Against Virally Induced Cancers;2007-09-28

3. Zervizitis (und Zervikovaginitis);Spezielle pathologische Anatomie;2001

4. Herpes Simplex Virus as a Cooperating Agent in Human Genital Carcinogenesis;Infectious Agents and Pathogenesis;1995

5. Precancerous Lesions of the Cervix;Blaustein’s Pathology of the Female Genital Tract;1994

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