Comparison of different vaccines and induced immune response againstCampylobacter jejunicolonization in the infant mouse

Abstract

SUMMARYThe degree of protection conferred by vaccinated dams on infant mice against colonization byCampylobacter jejunidepended on the bacterial strain, preparation, and route of administration of the vaccine. In some instances of homologous protection, serum bactericidal titres correlated well with protection. However, boiledC. jejunivaccine, which was non-protective, also elicited a strong bactericidal antibody response. Conversely, bactericidal activity could not be demonstrated against strains capable of cross-protection. There was a good correlation between high campylobacter-specific IgG response and bactericidal activity.