Author:
van der HEIJDEN O. G.,CONYN-van SPAENDONCK M. A. E.,PLANTINGA A. D.,KRETZSCHMAR M. E. E.
Abstract
In order to improve the prevention of cases of congenital rubella
syndrome in The
Netherlands, in 1987 the selective vaccination strategy against rubella
infection in girls was
replaced by mass vaccination. This decision was supported by mathematical
model analyses
carried out by Van Druten and De Boo. In order to compare the predicted
impact of the
rubella vaccination programme with the current available data in more detail,
a similar model
was built. Although the model predicts elimination of the rubella virus,
data show that virus
circulation is still present at a higher level than expected by the model.
Simulation studies
indicate that import of infection and a lower vaccine effectiveness, related
to possible
asymptomatic reinfection of vaccinated people, could be sources contributing
to the present
virus circulation. Even though the number of infections is much higher
than the number of
reported cases of disease, limited serosurveillance data and case notification
data show that
females of childbearing age are well protected by immunization.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
16 articles.
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