Author:
Jaiyesimi Olufemi,Baichoo Vijaymani
Abstract
Background and aim: Reports from several countries suggest that the prevalence and spectrum of the congenital cardiac malformations seen in the setting of Down's syndrome vary in different ethnic groups and countries, and at different periods in the same country. Data on Arab children are lacking. Our study aimed to fill that void by ascertaining the pattern in Omani Arabs. Methods: Prospective clinical and echocardiographic evaluation of consecutively recruited Omani children with Down's syndrome. Results: We studied 110 children, aged from one day to 11 years, with a median of 2 months, detecting 76 cardiovascular malformations in 63 (57%) of them. Atrioventricular septal defect, the most prevalent lesion, accounted for 24 (32%) of the 76 defects. Next were atrial septal defects within the oval fossa (29%), patency of the arterial duct (17%), and ventricular septal defect (14%). There were only two cases of Fallot's tetralogy, one each of coarctation of the aorta and right-sided heart, respectively; and none of discordant ventriculo-arterial connections. Conclusion: The prevalence of cardiovascular malformations is high, at 57%, in our studied population of Arab children. Overall, 92% of the malformations are defects which are characterized by a left-to-right shunt, and the potential for pulmonary hypertension. These findings underscore the need for early detection and prompt, appropriate care. To achieve this, if feasible, all babies born with Down's syndrome should have echocardiography in the first month of life.
Publisher
Cambridge University Press (CUP)
Subject
Cardiology and Cardiovascular Medicine,General Medicine,Pediatrics, Perinatology and Child Health
Reference30 articles.
1. Fuentes JJ , Prichard MA , Planas AM , Bosch A , Ferrer I , Estivill X . A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet 1995; 4: 1935–1944.
2. Digilio C . Cardiac defects in Mexican children with Down syndrome (Letter). Rev Esp Cardiol 2004; 57: 482.
3. Freeman SB , Taft LF , Dooley KJ , et al. Population-based study of congenital heart disease in Down syndrome. Am J Med Genet 1998; 80: 213–217.
4. Stoll C , Alembik Y , Dott B , Roth MP . Study of Down syndrome in 238,942 consecutive births. Ann Genet 1998; 41: 44–51.
5. Khoury MJ , Erickson JD . Improved ascertainment of cardiovascular malformations in infants with Down's syndrome, Atlanta, 1968 through 1989. Am J Epidemiol 1992; 136: 1457–1464.
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