Author:
Wongkamchai S.,Rochjanawatsiriroj C.,Monkong N.,Nochot H.,Loymek S.,Jiraamornnimit C.,Hunnangkul S.,Choochote W.
Abstract
AbstractTo study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.
Publisher
Cambridge University Press (CUP)
Subject
Animal Science and Zoology,General Medicine,Parasitology
Reference23 articles.
1. Impact of filariasis control programme on intestinal helminthic infection, A pilot study in Narathiwart province, Thailand;Loymek;Southeast Asian Journal of Tropical Medicine and Public Health,2004
2. Longitudinal analysis of the development of filarial infection and antifilarial immunity in a cohort of Haitian children.
3. Age Specific Patterns of Change in the Dynamics of Wuchereria bancrofti Infection in Papua New Guinea
4. Wuchereria bancrofti filariasis in French Polynesia: age-specific patterns of microfilaraemia, circulating antigen, and specific IgG and IgG4 responses according to transmission level. I;Chanteau;Journal of Parasitology,1995
5. Anti‐filarial IgG4 in men and women living in Brugia malayi‐endemic areas
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