Author:
Ligthart Lannie,van Beijsterveldt Catharina E.M.,Kevenaar Sofieke T.,de Zeeuw Eveline,van Bergen Elsje,Bruins Susanne,Pool René,Helmer Quinta,van Dongen Jenny,Hottenga Jouke-Jan,van’t Ent Dennis,Dolan Conor V.,Davies Gareth E.,Ehli Erik A.,Bartels Meike,Willemsen Gonneke,de Geus Eco J.C.,Boomsma Dorret I.
Abstract
AbstractThe Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources — the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping — allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.
Publisher
Cambridge University Press (CUP)
Subject
Genetics (clinical),Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Cited by
102 articles.
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