Author:
Brady Margaret I.,Furminger I. G. S.
Abstract
SummaryConventional influenza vaccine containing whole virus particles purified on a zonal centrifuge is pyrogenic and can cause systemic and local adverse side effects. An improved vaccine was therefore prepared which contained only the surface antigens of the virus adsorbed to aluminium hydroxide. The antigenicity of this vaccine was compared with conventional vaccine in chickens. Both vaccines induced similar titres of serum haemagglutination-inhibition and neuraminidase inhibition antibody. The dose response curves, however, were different. The surface antigens at vaccine strength without aluminium hydroxide were of negligible pyrogenicity in rabbits.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Immunology
Reference26 articles.
1. World Health Organization (1953). First report of the expert committee on influenza.
2. The protection of ferrets against influenza by immunization with a split influenza vaccine. International symposium on immunity to infections of the respiratory system;Brady;Developments in Biological Standardisation,1975
3. The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses
4. Studies on Vaccination of Infants Against Influenza with Influenza Hemagglutinin
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