Author:
Feery Brian J.,Evered M. G.,Hayes Kathleen
Abstract
SummaryIn a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/ 840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (H0N1).There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Immunology
Reference17 articles.
1. Advanced laboratory techniques for influenza diagnosis;Palmer;US Department of Health, Education and Welfare,1975
2. Effect of dose on antibody response to subunit influenza vaccine;Feery;Medical Journal of Australia,1977
3. Influenza in a Partially Immunized Aged Population
4. Immunological interrelationships of Hong Kong, Asian and Equi 2 influenza viruses in man;Marine;Bulletin of the World Health Organization,1969
5. On the doctrine of original antigenic sin;Francis;Proceedings of the American Philosophical Society,1960
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