The effects of morphine, diacetylmorphine and some related alkaloids upon the alimentary tract: Part V. A discussion on the probable mechanism of the constipating action of morphine

Abstract

1. The mechanical effects of morphine, heroin, codeine, dilaudid, dicodid, and eukodol upon the alimentary tract are discussed and contrasted.2. The results of these mechanical effects upon the passage of food along the alimentary canal are discussed.3. The constipating action of morphine is explained upon an almost purely mechanical basis.4. From experimental evidence it is concluded that dilaudid is probably a constipating drug although this effect may not be so marked as that produced by morphine.5. There is no experimental evidence to suggest that the administration of dicodid would ever produce constipation.6. It is suggested that small doses of eukodol are not constipating, whereas large doses, in certain circumstances which are discussed, may produce a mild degree of constipation.