Conversion of Bordetella pertussis to Bordetella parapertussis

Author:

Kumazawa Norichika H.,Yoshikawa Masanosuke

Abstract

SUMMARYThe epidemiological and drug susceptibility data on whooping cough suggested a possibility that Bordetella pertussis converts in some way to Bordetella parapertussis. To prove this, B. pertussis strain 75 was treated with N-methyl-N'-nitro-N-nitrosoguanidine and a mutant resistant to staphcillin V and eight mutants resistant to trimethoprim were isolated. The staphcillin V-resistant mutant of B. pertussis agreed with all of the criteria of B. parapertussis and the trimethoprimresistant mutants also agreed with many of these criteria. Thus, a hypothesis is presented that B. parapertussis is a mutant of B. pertussis which appeared in nature probably by a selective pressure of antibiotics.

Publisher

Cambridge University Press (CUP)

Subject

Public Health, Environmental and Occupational Health,Immunology

Cited by 23 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

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2. A Causal Relationship between Bordetella pertussis and Bordetella parapertussis Infections;Scandinavian Journal of Infectious Diseases;1996-01

3. Primum non nocere;The Pediatric Infectious Disease Journal;1993-10

4. Population Genetics of Bacterial Pathogenesis;Molecular Basis of Bacterial Pathogenesis;1990

5. In vitro susceptibility of Bordetella parapertussis to various antimicrobial agents;Antimicrobial Agents and Chemotherapy;1989-06

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