Criteria for measuring the efficacy of trachoma vaccines in baboons

Author:

Collier L. H.,Lightman Elaine

Abstract

SUMMARYTrachoma vaccines are usually assayed by testing their ability to protect monkeys or baboons against subsequent challenge of the conjunctiva with a pathogenic strain of trachoma/inclusion conjunctivitis (TRIC) agent. In such experiments the course of infection in vaccinated baboons was compared in terms of arbitrary scores assigned to a range of clinical signs, and of counts of TRIC inclusions in conjunctival scrapings. Analysis of many such scores indicated that after a large challenge dose of strain MRC-4s, the scores for signs of inflammation reached their maximum earlier than the follicle score; the inflammation score was closely related to the number of inclusions, whereas the follicle score was not. With this system, the optimum periods for eliciting differences between vaccinated and control measures varied according to the sign used; it was later for follicles than for inflammation or inclusions. For assessing the influence of vaccination, the mean of the inflammation scores read weekly for the first 3 weeks after challenge and the mean inclusion score over the same period were equally satisfactory, and either was rather better than the mean of three follicle scores taken over the period 3–6 weeks.For assessing the influence of vaccines or therapeutic agents on experimental trachoma it is important to determine which signs discriminate best between treated and control animals, and the optimum times for measuring them.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Epidemiology

Reference16 articles.

1. World Health Organization (1966). Fourth Scientific Group on Trachoma Research. Technical Report Series, World Health Organization, no. 330.

2. Nomenclature of Isolates of Virus from Trachoma and Inclusion Blennorrhea

3. INFECTION OF RHESUS AND CYNOMOLGUS MONKEYS WITH EGG-GROWN VIRUSES OF TRACHOMA AND INCLUSION CONJUNCTIVITIS*

4. Trachoma Viruses Isolated in the United States. 4. Infectivity and Immunogenicity for Monkeys

5. Trachoma: studies of etiology, laboratory diagnosis, and prevention;Grayston;Journal of the American Medical Association,1960

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Lids, Conjunctiva, and Lacrimal Apparatus;Archives of Ophthalmology;1975-09-01

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