Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Abstract

SUMMARYIn the first of two experiments 45 ewes were treated on day 141 of gestation with either prostaglandin F2a or saline. Doses of 10, 15, 20 or 25 mg PGF2a failed to induce lambing earlier than in control animals. A further 50 ewes were similarly treated on day 144; neither dose level of PGF2a nor day of administration had any effect on the interval from injection to lambing compared with controls. In a second experiment 159 ewes were randomly assigned to one of four treatment groups as follows: (1) 20 mg oestradiol benzoate (ODB); (2) 16 mg dexamethasone; (3) 15 mg PGF2a; (4) 2 ml saline. Ewes were injected on either day 143 or 144 of gestation and on each of those days animals were injected either in the morning or evening. The mean times to induction of lambing were 38·6 ± 20·8; 44·2 ± 18·1; 83·5 ± 39·8 and 82·9 ± 43·1 h for the four treatments respectively. Neither day nor time of treatment had any significant effect on the interval to lambing. Both ODB and dexamethasone induced parturition earlier than PGF2a or saline (P < 005).