Preclinical models of antipsychotic drug action-Reference-Cited by-同舟云学术

Preclinical models of antipsychotic drug action

Published:2013-11-01 Issue:10 Volume:16 Page:2131-2144
ISSN:1469-5111
Container-title:International Journal of Neuropsychopharmacology
language:en
Short-container-title:

Author:

Moreno José L.¹,González-Maeso Javier¹²³

Affiliation:

1. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA

2. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA

3. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA

Abstract

Abstract One of the main obstacles faced by translational neuroscience is the development of animal models of psychiatric disorders. Behavioural pharmacology studies indicate that psychedelic drugs, such as lysergic acid diethylamide (LSD) and dissociative drugs, such as phencyclidine (PCP), induce in healthy human volunteers psychotic and cognitive symptoms that resemble some of those observed in schizophrenia patients. Serotonin 5-HT2A and metabotropic glutamate 2 receptors have been involved in the mechanism of action of psychedelic and dissociative drugs. Here we review recent advances using LSD-like and PCP-like drugs in rodent models that implicate these receptors in the neurobiology of schizophrenia and its treatment.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://academic.oup.com/ijnp/article-pdf/16/10/2131/30135780/16-10-2131.pdf

Reference187 articles.

1. Schizophrenia: the drug deadlock;Abbott;Nature,2010

2. Addex Therapeutics (2012) Available at: http://www.addextherapeutics.com/investors/press-releases/news-details/article/addex-reports-top-line-data-from-a-successful-phase-2a-clinical-study-with-adx71149-in-schizophrenia/.

3. Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia;Adler;Am J Psychiatry,1999

4. Modeling ‘psychosis’ in vitro by inducing disordered neuronal network activity in cortical brain slices;Aghajanian;Psychopharmacology (Berl),2009

5. Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected;Agid;Arch Gen Psychiatry,2003

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