The effect of 6-dimethylaminopurine (6-DMAP) on DNA synthesis in activated mammalian oocytes-Reference-Cited by-同舟云学术

The effect of 6-dimethylaminopurine (6-DMAP) on DNA synthesis in activated mammalian oocytes

Published:1996-02 Issue:1 Volume:4 Page:7-9
ISSN:0967-1994
Container-title:Zygote
language:en
Short-container-title:Zygote

Author:

Ledda S.,Loi P.,Bogliolo L.,Moor R.M.,Fulka J.

Abstract

SummaryMouse, sheep and bovine metaphase II oocytes were briefly preincubated in medium with 6-dimethyl-aminopurine (6-DMAP) and thereafter activated with ethanol before further culture in 6-DMAP supplemented medium. The presence of 6-DMAP enhances the efficiency of activation and the speed of pronuclear formation but has no effect on DNA synthesis. These results are discussed in the context of recently published data showing that the preincubation of condensed chromosomes with 6-DMAP blocks DNA synthesis when nuclei become reformed.

Publisher

Cambridge University Press (CUP)

Subject

Cell Biology,Developmental Biology

Reference12 articles.

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4. Purification of an MCM-containing complex as a component of the DNA replication licensing system

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