Natural History of the Vascular Dementias: A Prospective Study of Seven Cases

Author:

Hershey Linda A.,Modic Michael T.,Jaffe David F.,Greenough P. Gregg

Abstract

Abstract:The clinical course of vascular dementia has been described as a stepwise deterioration over time. We studied the chronologic course of cognitive performance over 1-4 years in seven patients with known ischemic cerebrovascular disease whose dementia subtype was assigned according to the clinical history and the pattern of white matter lesions seen on magnetic resonance imaging (MRI). One patient had the lacunar state, three had subcortical arteriosclerotic encephalopathy and three had multiple cortical and subcortical strokes. All were being treated with an antiplatelet agent and six received antihypertensive therapy. Four of the seven vascular dementia patients improved cognitively over the first year. A fluctuating course was eventually seen in all patients. None showed stepwise deterioration of cognitive function over time. The MRI was useful in subclassifying vascular dementia patients, but the clinical course did not appear to vary as a function of the dementia subtype.

Publisher

Cambridge University Press (CUP)

Subject

Neurology (clinical),Neurology,General Medicine

Cited by 24 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Types of memory, dementia, Alzheimer’s disease, and their various pathological cascades as targets for potential pharmacological drugs;Ageing Research Reviews;2024-04

2. Vascular Cognitive Impairment;Ischemic Stroke Therapeutics;2024

3. Psychological assessment of the elderly;Handbook of Psychological Assessment;2019

4. Dementias;Atlas of Clinical Neurology;2019

5. Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2016-05

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