Author:
Melançon S.B.,Grignon B.,Ledru E.,Geoffroy G.,Potier M.,Dallaire L.,Vanasse M.
Abstract
SUMMARY:Taurine and β-amino uptake in cultured skin fibroblasts proceeds through at least two distinct amino acid transport systems. The predominant Bamino acid uptake system which we refer to as the “Beta” system, incorporates taurine in a proportion of 95%, β-alanine in a proportion of 80% and does not incorporate β-amino-isobutyric acid. A second transport system for β-alanine seems to be operative in cultured skin fibroblasts and this system shares the characteristics of system “L” for branched-chain and ringside neutral amino acids. Results of ion depletion experiments, metabolic inhibition by drugs and blocking agents and previous kinetic studies of taurine and β-alanine uptake in cultured skin fibroblasts failed to disclose any major difference in β-amino acid transport between control individuals and patients with Friedreich's ataxia.
Publisher
Cambridge University Press (CUP)
Subject
Clinical Neurology,Neurology,General Medicine
Reference31 articles.
1. Taurine transport in renal brush-border-membrane vesicles
2. Dicarboxylic Amino Acid Uptake in Normal, Friedreich's Ataxia, and Dicarboxylic Aminoaciduria Fibroblasts
3. High-affinity transport of taurine and β-alanine and low affinity transport of 7-aminobutyric acid by a single transport system in cultured glioma cells;Martin;J. Biol. Chem,1979
4. Adrenergic Stimulation of Taurine Transport by the Heart
5. Taurine sodium-dependent, high affinity transport into rat brain synaptosomes;Hruska;Molec. Pharmacol,1978
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献