Cerebral Glucose Metabolism in Parkinson’s Disease

Author:

Martin W.R.W.,Beckman J.H.,Calne D.B.,Adam M.J.,Harrop R.,Rogers J.G.,Ruth T.J.,Sayre C.I.,Pate B.D.

Abstract

ABSTRACTLocal cerebral glucose utilization was measured in patients with predominantly unilateral Parkinson’s disease using 18F-2-fluoro-deoxyglucose and positron emission tomography. Preliminary results indicate the presence of asymmetric metabolic rates in the inferior basal ganglia. The structure comprising the largest portion of basal ganglia at this level is globus pallidus. These findings are consistent with metabolic studies on animals with unilateral nigrostriatal lesions in which pallidal hypermetabolism on the lesioned side has been demonstrated. Increased pallidal activity is likely secondary to a loss of inhibitory dopaminergic input to the striatum from substantia nigra.

Publisher

Cambridge University Press (CUP)

Subject

Clinical Neurology,Neurology,General Medicine

Reference20 articles.

1. Plasticity of [14C]2-deoxy-d-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement

2. Alternative formula for glucose utilization using labeled deoxyglucose;Brooks;J. Nucl. Med,1982

3. Adam MJ (1982) A rapid, stereoselective, high yielding synthesis of 2-deoxy-2-fluor-D-hexopyranoses: reaction of glycals with acetyl hypofluorite. J. Chem. Soc. Chem. Commun. 730.

4. Effects of substantia nigra lesions on forebrain 2-deoxyglucose retention in the rat

5. Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake

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