The Differences of Electrolyte and Cardiac Markers Levels in NSTEMI and STEMI Patients

Abstract

Background: Coronary heart disease (CHD) has become the leading cause of mortality in the world. Myocardial infarction is the most common form of CHD, which consists of NSTEMI and STEMI. Differences of sodium, potassium, chloride, troponin I and NT-ProBNP levels on NSTEMI and STEMI were not widely discussed. Previous studies of electrolyte levels and NT-ProBNP gave different results. Aim: To analyze the differences of serum sodium, potassium, chloride, troponin I and NT-ProBNP levels in NSTEMI and STEMI patients. Methods: Analytic observational study design with cross sectional approach was conducted in February-May 2019 involving 35 NSTEMI and 35 STEMI patients at the Dr. Kariadi General Hospital ED who were screened according to the inclusion and exclusion criteria. Sodium, potassium and chloride levels were measured using the ISE method of the Advia biochemistry system. Troponin I levels were measured by the ELFA method on Vidas mini and NT-ProBNP levels were using the ELISA method. Differences in sodium, potassium and chloride levels between groups were analyzed using independent t-test, differences in troponin I and NT-ProBNP levels between groups were analyzed using Mann Whitney U Test. p values were considered significant if less than 0.05. Results: There are significant differences in levels of sodium (p=0.001), chloride (p=0.030), troponin I (p<0.001) and NT-ProBNP (p=0.001) between NSTEMI and STEMI patients. The difference of potassium levels is not significant between the two groups (p=0.721). Conclusion: Lower levels of sodium and chloride, higher troponin I and NT-ProBNP levels occur in STEMI rather than NSTEMI. Keywords: Electrolyte, Troponin I, NT-ProBNP, NSTEMI, STEMI