Etiology of Hepatocellular Carcinoma and Association with Hepatitis B & C Virus

Abstract

Aim: To evaluate the association of hepatitis with the hepatocellular carcinoma. Hepatitis is known as the inflammation of the liver. Methods: Hepatitis C and B may lead to HCC (hepatocellular carcinoma), such as Hepatitis B may cause 50% and hepatitis C is responsible for 70 to 80 % of cases of HCC. Obesity, alcohol and type 2 diabetes are also a predisposing factor for HCC. HCC is the malignant tumor, and have a low survival rate due to reoccurrence. Results: Eighty two patients were selected with hepatitis and HCC. This cross-sectional study was conducted at Allied Hospital Faisalabad. Ultrasound machine of Toshiba was used with a transducer of frequency 3-6MHz for the liver scanning. 82 patients with hepatitis B, C, and HCC were included in this study. Out of 82 patients, 55 were male and 27 were female. The mean age was 55yrs. Group A 45 (54%) patients were infected with hepatitis C and Group B 35(42%) patients were infected with hepatitis B. Hepatitis C is the most common cause of HCC as compared to hepatitis B. Conclusion: In this study, it is concluded that there is a positive association between hepatitis and Hepatocellular Carcinoma. The patient infected with hepatitis C is more prone to develop HCC than those infected with hepatitis B. Keywords: HCC (hepatocellular carcinoma), Hepatitis B, C, lesion.