Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Composite Nanosilver (AgNPs) - Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study

Abstract

Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim: the aim was to evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried, and the results showed that the percentage of a reduction rate of the ulcer by the third week of the treatment as in the hydrogel/nano silver-based dressing group was higher (15.11%) than traditional wound dressing group (33.44%). Moreover, the mean ulcers size "sq mm" in the hydrogel/nano silver-based dressing group recognized a faster healing rate (15.11 ± 7.89), and considerably lesser in comparison to the traditional by the third week (21.65 ± 8.4). Conclusion: The hydrogel/nanosilver-based dressing showed better results than traditional dressing in managing diabetic ulcer foot. Keywords: Diabetes, Wound, Diabetic ulcer, Wound dressing, Nanomedicine, Nano-silver.