Frequency of Dyslipidemia in patients with Psoriasis and Association with Disease Severity

Abstract

Background: Psoriasis is a recurrent disfiguring skin disease, associated with abnormal lipid metabolism and with high occurrence of cardiovascular complications. This linked to the extent of disease, as it is often seen in those patients who have larger body areas involved with psoriasis. Objective: To estimate frequency of dyslipidemia in psoriatic patients and to determine the frequency of dyslipidemia in psoriatic patients based on the severity of disease. Study Design: Cross-sectional study Place and Duration of Study: Department of Dermatology, Fauji Foundation Hospital Rawalpindi from 1stMarch 2017 to 30th September 2017. Methodology: One hundred and fifty cases were enrolled. All cases were enrolled and 3ml of blood was collected following 12 hrs of fasting for determination of lipid profile. Blood sample was sent to the Hospital laboratory and reports were verified by senior pathologists. Severity of psoriasis was determined according to PASI score. Results: Age of participants was between 18-60 years with mean 38.88±12.26 years and 29 (19.33%) male and 121 (80.67%) female cases. According to severity of disease, 50 (33.3%) cases had mild, 70 (46.7%) had moderate and 30(20%) cases had severe Psoriasis. The mean cholesterol, triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) was 12.91 ± 2.17, 8.93 ± 2.90, 5.0 ± 2.28 and 1.98 ± 0.31 respectively. There were 100(66.7%) cases who had dyslipidemia and 50(33.3%) had normal lipid profile. Conclusion: Frequency of dyslipidemia is very high and is associated with severity of psoriasis. Keywords: Psoriasis, Dyslipidemia, Lipid profile and Cardiovascular disease.