Association of Blood Groups with Oral Submucous Fibrosis and if any of the Blood Group is Related with an Increased Risk for Oral Submucous Fibrosis

Abstract

Objective: To assess any association of blood groups with oral submucous fibrosis and if any of the blood group is related with an increased risk for oral submucous fibrosis. Study Design: Comparative study Place and Duration of Study: Department Of Oral Pathology, Fatima Jinnah Dental College & Hospital Karachi, Pakistan from Jan to Dec 2018. Patients and Methods: Total 100 patients were enrolled in the study in which half were cases where oral sub mucous fibrosis had been diagnosed clinically while remaining half were the controls that were involved in the habit of using tobacco/nuts but had no oral pre malignant lesion. For investigation of blood, samples of blood were taken from both the groups. Odd ration and chi-square test was used to analyze data. A p-value of <0.05 was considered statistically significant. Results: Majority of the individuals in experimental group had “B” blood group followed by “O” “AB” and “A” blood groups. Conclusion: This study showed that ABO blood groups have considerable relation with oral submucous fibrosis. Individuals having “B” blood group had 2.18 times increased tendency of having oral submucous fibrosis in contrast with patients who belong to any other blood group. Keywords: ABO blood group system, Oral Submucous fibrosis, Oral lesions, Oral Squamous Cell Carcinoma