The Preventive Effects of two Different Doses of Dexmedetomidine on Shivering in Cesarean Section under Spinal Anesthesia

Abstract

Introduction: One of the side effects caused by spinal anesthesia is seizures of impaired body temperature regulation, which in addition to causing concern for the mother, can lead to problems such as cardiovascular and respiratory disorders. This has led to the choice of the appropriate drug to reduce shivering, with the least neonatal and maternal side effects in cesarean section. The main purpose of this study was to compare the prophylactic effect of intravenous dexmedetomidine at two different doses for cesarean section induced shivering under spinal anesthesia. Methods: This article is a double blind randomized clinical trial study performed in Isfahan University of Medical Sciences (Alzahra and Shahid Beheshti). The target population of the study was pregnant women with indication of cesarean section. In this study 60 pregnant women were divided into three groups. In the first group patients were injected with 2.5 mg / kg dexmedetomidine, in the second group patients with 5 mg / kg dexmedetomidine and in the third group with similar volume, normal saline was injected and the shivering intensity in patients with the use of Grassi and Mahajan criteria was evaluated. Finally, the collected data were analyzed using SPSS software and Kruskal-Wallis One-Way ANOVA tests. Results: According to the statistical analysis of the data, after cesarean section with spinal anesthesia, shivering intensity in the 5mg / kg dexmedetomidine group was lower than in the 2.5mg group and less than the control group. Normal saline was given as prophylaxis. Conclusion: Intravenous dexmedetomidine, especially at a dose of 5 μg / kg, has a significant effect on reducing postoperative shivering by cesarean section with spinal anesthesia. Keywords: Dexmedetomidine, Shivering, Cesarean section, Spinal anesthesia